2019 Post-doctoral Non-clinical Fellowship
Multifactorial Integrative Network Inference of NeurodeGeneration (MINING)
Neurodegeneration impacts brain function years before symptoms, presenting both a challenge and an opportunity to understand, treat and ultimately prevent dementia. The challenge lies in understanding why certain individuals can remain functionally resilient to advancing neuropathology and atrophy, and what determines their eventual conversion to a symptomatic state. Conversely, the opportunity lies in identifying the drivers of disease progression at the stage when intervention would be most desirable and effective.
This endeavour requires identifying the factors that moderate large-scale neural dynamics, while considering genetics, lifestyle, and overall health, and their consequences for cognitive function. The primary focus of the work was on providing an understanding of latent disease and conversion, through the integration of multimodal quantitative measures of brain structure, function and connectomics as determinants of cognition. By leveraging data from cohorts with known genetic risk and employing multivariate imaging analysis, I studied the critical role of neural dynamics in supporting cognitive ability in the presence of progressive yet presymptomatic pathology.
The Fellowship allowed me to develop a novel framework and advance multivariate methodologies aimed at determining the distinct contributions of brain structure and function that are linked to differences in cognitive abilities. This work enabled me to obtain Alzheimer’s Society Dementia Research Leader Fellowship, where my research will focus on studying the brain changes underlying functional resilience in relation to genetic, vascular and comorbidity factors.
Publications
Cognition's dependence on functional network integrity with age is conditional on structural network integrity
Neurobiology of Aging, 2023, https://doi.org/10.1016/j.neurobiolaging.2023.06.001
2023
Reduced locus coeruleus integrity linked to response inhibition deficits in parkinsonian disorders
Journal of Neuroscience, 2023 43 (42), 7928-7040, https://doi.org/10.1523/JNEUROSCI.0289-22.2023
2023
Early neurotransmitters changes in prodromal frontotemporal dementia: A GENFI study
Neurobiology of disease 179, 106068, https://doi.org/10.1016/j.nbd.2023.106068
2023
Neural Evidence of Functional Compensation for Fluid Intelligence in Healthy Ageing
bioRxiv, 2023.09. 29.560099
2023
Evaluating models of the ageing BOLD response
bioRxiv, 2023.08. 24.554634
2023
Associative memory is more strongly predicted by age-related differences in the prefrontal cortex than medial temporal lobes
Neuroimage: Reports 2023, 3 (2), 100168
2023
Lifespan differences in visual short-term memory load-modulated functional connectivity
NeuroImage 2023, 270, 119982
2023
Microglial activation in the frontal cortex predicts cognitive decline in frontotemporal dementia
Brain, 2023;, awad078, https://doi.org/10.1093/brain/awad078
2023
Distinct components of cardiovascular health are linked with age-related differences in cognitive abilities
Scientific Reports 2023 13 (1), doi: 10.1038/s41598-022-27252-1
2023
Cognition's dependence on functional network integrity with age is conditional on structural network integrity
bioRxiv, 2023 2023.01. 02.522493
2023
Cerebral blood flow predicts multiple demand network activity and fluid intelligence across the adult lifespan
Neurobiology of aging 2023 121, 1-14
2023
Multimodal fusion analysis of functional, cerebrovascular and structural neuroimaging in healthy aging subjects
Human Brain Mapping 2022 43 (18), 5490-5508
2022
In vivo 18F-flortaucipir PET does not accurately support the staging of progressive supranuclear palsy
Journal of Nuclear Medicine 2022 63 (7), 1052-1057
2022
Quality assessment of anatomical MRI images from Generative Adversarial Networks: Human assessment and image quality metrics
Journal of Neuroscience Methods 2022 374, 109579
2022
Noradrenergic deficits contribute to apathy in Parkinson’s disease through the precision of expected outcomes
PLoS Computational Biology 2022 18 (5), e1010079
2022
Prefrontal cortical connectivity mediates locus coeruleus noradrenergic regulation of inhibitory control in older adults
Journal of Neuroscience 2022 42 (16), 3484-3493
2022
Proton magnetic resonance spectroscopy in frontotemporal lobar degeneration-related syndromes
Neurobiology of aging 2022 111, 64-70
2022
The role of the arousal system in age‐related differences in cortical functional network architecture
Human Brain Mapping 2022 43 (3), 985-997
2022
The “Neural Shift” of Sleep Quality and Cognitive Aging: A Resting-State MEG Study of Transient Neural Dynamics
Frontiers in Aging Neuroscience 2022 13, 987
2022
Hospitalisation for COVID-19 predicts long lasting cerebrovascular impairment: A prospective observational cohort study
NeuroImage: Clinical 2022 36, 103253
2022
Reduced locus coeruleus integrity linked to response inhibition deficits in parkinsonian disorders
medRxiv, 2021, 2021.10. 14.21264996
2021
Transient neural network dynamics in cognitive ageing
Neurobiology of Aging 2021 105, 217-228
2021
Locus coeruleus integrity and the effect of atomoxetine on response inhibition in Parkinson’s disease
Brain 2021 144 (8), 2513-2526
2021
Language disorder in progressive supranuclear palsy and corticobasal syndrome: neural correlates and detection by the MLSE screening tool
Frontiers in Aging Neuroscience 2021 13, 675739
2021
The effects of age on resting‐state BOLD signal variability is explained by cardiovascular and cerebrovascular factors
Psychophysiology 2021 58 (7), e13714
2021
Apathy in presymptomatic genetic frontotemporal dementia predicts cognitive decline and is driven by structural brain changes
Alzheimer's & Dementia 2021 17 (6), 969-983
2021
Brain functional network integrity sustains cognitive function despite atrophy in presymptomatic genetic frontotemporal dementia
Alzheimer's & Dementia 2021 17 (3), 500-514
2021
Correlation constraints for regression models: Controlling bias in brain age prediction
Frontiers in psychiatry 2021 12, 615754
2021
An in vivo probabilistic atlas of the human locus coeruleus at ultra-high field
NeuroImage 2021 225, 117487
2021
Separating vascular and neuronal effects of age on fMRI BOLD signals
Philosophical Transactions of the Royal Society B 2021 376 (1815), 20190631
2021
Dispersion of functional gradients across the adult lifespan
Neuroimage 2020 222 117299
2020