2021 NCPD Mansoureh Fahimi Hnazaee

Dr Mansoureh Fahimi Hnazaee

2021 Post-doctoral Non-clinical Fellowship

The role of the brainstem in pathological beta oscillations in Parkinson’s disease: evidence from human electrophysiology

Brain Stimulation (DBS) is an invasive treatment to restore function to Parkinson’s Disease (PD) patients in the advanced stages of their condition. Despite the clinical improvement of DBS, its physiological basis is not fully understood. DBS provides a unique window into the human brain as, under certain conditions, one can record from the electrodes implanted in target brain nuclei, most commonly, the subthalamic nucleus (STN) in the basal ganglia (BG). Local field potentials (LFP) in the STN revealed synchronized neural oscillations in different frequency bands, mostly the beta-band. Beta-oscillations are modulated by dopaminergic drugs and DBS, and considered to play a role in generating bradykinesia. Nonetheless, the exact mechanism behind this is unclear. While previous models have mainly focused on the cortico-BG-thalamo-cortical circuitry, there is contradictory evidence as to whether beta-oscillations in the cortex are modulated by the BG. An insufficiently explored aspect is the connection of BG to several key structures in the brainstem, such as the pedunculopontine nucleus (PPN) that modulate locomotion, and are damaged in PD. However, investigating the oscillatory dynamics of the brainstem is challenging, due to technical limitations in recording human electrophysiology from subcortical structures in vivo. In this project, I will combine cutting-edge neuroimaging techniques with the latest advances in DBS technology to test the hypothesis that pathological beta oscillations of the BG are propagated to the brainstem. A clarification of the role of the brainstem in PD will lead to a better understanding of how pathological beta-oscillations are linked to the condition. Consequently, surgical targeting and stimulation programming can be optimised by focusing on the most relevant fibre tracts and new targets for DBS can be identified.

2021 NCPD Mansoureh Fahimi Hnazaee Figure


Combining video telemetry and wearable MEG for naturalistic imaging

O'Neill, George C., Robert A. Seymour, Stephanie Mellor, Nicholas Alexander, Tim M. Tierney, Lea Bernachot, Mansoureh Fahimi Hnazee et al

bioRxiv (2023): 2023-08


Investigating cortico-striatal beta oscillations in Parkinson’s disease cognitive decline

Fahimi Hnazaee, Mansoureh, and Vladimir Litvak

Brain 146, no. 9 (2023): 3571-3573


Motor and non-motor network characterization with combined telemetric local field potentials and EEG recordings

Fahimi Hnazaee, Mansoureh

Brain Stimulation: Basic, Translational, and Clinical Research in Neuromodulation 16, no. 1 (2023): 150


Combining Magnetoencephalography with Telemetric Streaming of Intracranial Recordings and Deep Brain Stimulation–a Feasibility Study

Fahimi Hnazaee, Mansoureh, Matthias Sure, George O’Neill, Gaetano Leogrande, Alfons Schnitzler, Esther Florin, and Vladimir Litvak

Imaging Neuroscience


Pin-prick stimulation: EEG evoked potentials, spectra and source localization

Tedesco Triccas L, Camilleri K, Camilleri TC, Fahimi Hnazaee M, Wittevrongel B, Muscat F, Boccuni L, Melis E, Paulissen N, Mantini D, Verheyden G

Frontiers in Human Neuroscience 16 (2022): 881291


Towards Predicting ECoG-BCI performance: Assessing the Potential of scalp-EEG

Fahimi Hnazaee, Mansoureh, Zachary V Freudenburg, Maxime Verwoert, M.A. van der Salm, Sandra, Aarnoutse, Erik, Leinders, Sacha Van Hulle, Marc M. Ramsey, Nick F., Vansteensel, Mariska J

Journal of Neural Engineering 19.4 (2022): 046045